What is the definition of tolerance in medication use?

The definition of tolerance in medication use refers to a phenomenon where a patient requires a higher dose of a medication to achieve the same therapeutic effect that was previously attained with a lower dose. This typically occurs because the body becomes accustomed to the presence of the drug, leading to reduced sensitivity to its effects over time. Tolerance can develop for various types of medications, particularly those used for pain relief, anxiety, or other conditions that may require long-term management. Understanding tolerance is crucial for safe medication administration and for monitoring patient responses to therapy, ensuring that healthcare providers adjust dosages appropriately while considering the individual needs of the patient.