What factors can decrease topical medication absorption?

Decreased absorption of topical medications can occur due to factors like wrinkled skin and decreased blood flow. When skin is wrinkled, it may have a compromised barrier function, which can disrupt the ability of the medication to penetrate effectively. Additionally, decreased blood flow in certain areas limits the distribution of the medication through the skin, reducing its overall absorption and effectiveness. This means that the medication may not reach the systemic circulation or the intended site of action as effectively as it would under optimal conditions.

In contrast, factors like increased hydration of the skin can enhance absorption because hydrated skin allows for better interaction with the medication. Increased hair follicles generally do not contribute to decreased absorption; instead, they can act as pathways for some medications. Healthy skin typically promotes better absorption due to its intact barrier properties and adequate blood flow.