What can happen if a drug accumulates in the body?

When a drug accumulates in the body, it can lead to toxicity, which is when the levels of the drug exceed the therapeutic range, potentially causing harmful effects. This accumulation can occur for various reasons, including impaired metabolism or excretion, or excessive dosing. The result of this toxicity can manifest as adverse reactions or side effects that can be severe or dangerous. Understanding the risk of drug accumulation is crucial in medication management, as it highlights the importance of adhering to prescribed dosages and monitoring patients for signs of toxicity, particularly in those with compromised kidney or liver function, where drug clearance may be impacted.